Executive Director, Clinical Pharmacology

Janux Therapeutics is seeking a hands-on, execution-driven Executive Director of Clinical Pharmacology to lead the design, analysis, and interpretation of clinical pharmacology strategies across our development programs. This role is ideal for a scientific leader who thrives on rolling up their sleeves, working closely with data, and directly influencing clinical and regulatory outcomes.

As a key member of the clinical development leadership team, you will be responsible for both strategic direction and day-to-day execution of clinical pharmacology deliverables. You’ll work cross-functionally to ensure that pharmacokinetic (PK), pharmacodynamic (PD), and exposure-response data are fully leveraged to guide dose selection, study design, and regulatory strategy.

• Serve as the Clinical Pharmacology Lead for multiple programs, owning the strategy and execution of clinical pharmacology plans from IND through late-stage development.
• Design and oversee PK, PK/PD, and exposure-response analyses to support dose selection, study design, and benefit-risk assessments.
• Lead the development and execution of clinical pharmacology studies, including food effect, drug-drug interaction, organ impairment, and QT assessments.
• Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs, briefing books) and represent Janux in regulatory meetings.
• Ensure proper bioanalytical sampling strategies, assay validation, and data quality across studies.
• Partner with Translational, Pharmacology and/or Biomarker teams to integrate biomarker and mechanistic data into PK/PD models and clinical decision-making.
• Work closely with Biometrics to develop and validate population PK and exposure-response models.
• Provide scientific leadership and mentorship to internal team members, fostering a culture of collaboration, innovation, and accountability.
• Contribute to portfolio-level planning, helping prioritize programs and allocate resources based on pharmacological insights and development risk.
• Stay current with regulatory guidance and scientific advances in clinical pharmacology, applying best practices to Janux’s development programs
• Other activities as required.

• Ph.D., Pharm.D., or equivalent in Clinical Pharmacology, Pharmaceutical Sciences, or a related field.
• 10+ years of experience in clinical pharmacology and/or pharmacometrics in the biotech or pharmaceutical industry.
• Direct experience designing and executing early-phase clinical studies, including those involving healthy volunteers. Experience in oncology will be highly preferred.
• Demonstrated success in leading clinical pharmacology strategy and execution across multiple programs, in all phases of development.
• Deep expertise in model-informed drug development (MIDD), including population PK, PK/PD modeling, and exposure-response analysis.
• Strong track record of contributing to regulatory submissions and engaging with global health authorities.
• Excellent communication, leadership, and cross-functional collaboration skills.
• Strong organizational and time management abilities.
• High level of accountability, adaptability, and attention to detail.
• Ability to work independently and collaboratively in a fast-paced, matrixed environment.
• Ability to travel up to 15%

Job Type: Full-time

Benefits:

·         401K

·         Medical insurance

·         Dental insurance

·         Vision insurance

·         Supplemental disability insurance plans

·         Flexible schedule

·         Life insurance

·         Flexible vacation

·         Sick time

·         Incentive stock option plan

·         Relocation assistance

Schedule:

·         Monday to Friday

Work authorization:

·         United States (Required)

Additional Compensation:

·         Annual targeted bonus X%

Work Location:

·         On site (San Diego, CA)

EQUAL OPPORTUNITY EMPLOYER:

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party Agencies

The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.