Manager, Software Engineering

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook.

About Guardant Health

Guardant Health is a leading precision oncology company on a mission to conquer cancer through data. We develop innovative digital and data-driven solutions that empower clinicians and patients across the continuum of cancer care. Our software and platform engineering teams are foundational to enabling seamless integration of our genomic testing with healthcare providers, hospital systems, and laboratory partners around the country.

About the Role

We are seeking a Manager, Software Engineering to lead a highly collaborative team focused on clinical data integrations, EMR connectivity, and partnerships with hospital networks and reference labs. This is a Palo Alto–based leadership role that combines technical depth, team management, and stakeholder engagement—both internal and external.

You’ll be responsible for building and scaling cloud-native integration platforms, primarily using Java, MuleSoft, and AWS, to ensure Guardant’s digital infrastructure enables seamless interoperability with Epic, OncoEMR, hospital systems, and third-party labs. This role is critical to driving clinical adoption, operational efficiency, and data reliability across Guardant’s enterprise offerings.

Key Responsibilities

Team & Project Leadership

• Lead and mentor a team of backend and integration engineers focused on data exchange between Guardant and external clinical systems.

• Oversee delivery of EMR integrations, including Epic, OncoEMR, and other hospital EHR platforms.

• Drive development of scalable services and APIs that enable lab partnerships and external data connectivity.

Architecture & Execution

• Architect and scale MuleSoft-based integration flows and microservices that manage clinical and lab data pipelines.

• Ensure solutions are cloud-native, deployed on AWS/Kubernetes, and align with Guardant’s data security, compliance, and observability standards.

• Drive cross-functional initiatives by collaborating with Product, Clinical, Commercial, and Compliance teams.

External Stakeholder Engagement

• Serve as a technical point of contact for reference labs, hospital networks, and third-party integration partners.

• Work closely with external IT and data teams to define interface requirements, manage onboarding, and troubleshoot connectivity issues.

• Represent the engineering organization in strategic partner discussions, ensuring technical feasibility and long-term scalability.

Operational & Engineering Excellence

• Champion engineering best practices including CI/CD, test automation, observability, and resiliency.

• Monitor integration KPIs and operational metrics to ensure ongoing reliability and performance of partner-facing systems.

• Collaborate with peer leaders across Palo Alto and India to ensure delivery alignment and team health.

• 10+ years of software engineering experience, with at least 3+ years in a people management role, ideally leading backend or integration-focused teams.

• Deep experience with Java (Spring Boot) and MuleSoft in a production environment.

• Proven success with cloud-native development on AWS and Kubernetes.

• Experience delivering and maintaining integrations with EMRs (Epic, OncoEMR), hospital systems, or labs.

• Strong communication skills, including the ability to engage with external technical partners and cross-functional internal teams.

• Demonstrated ability to manage complex stakeholder needs, prioritize work across multiple initiatives, and deliver in a regulated environment.

Nice to Have

• Experience in Life Sciences, Diagnostics, or Healthcare IT.

• Familiarity with HL7, FHIR, and other healthcare interoperability standards.

• Experience working with Laboratory Information Management Systems (LIMS).

• Background in regulated environments including HIPAA, CAP/CLIA, or FDA guidelines.

Why Join Us?

At Guardant Health, your work enables faster and more effective cancer care. As an Engineering Manager, you’ll shape the integration layer that connects our genomic insights to real-world clinical systems, powering decisions that save lives. If you're passionate about scalable architecture, partner engagement, and engineering for impact—we want to hear from you.

Hybrid Work Model: At Guardant Health, we have defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.

For positions based in Palo Alto, CA or Redwood City, CA, the base salary range for this full-time position is $182,500 to $250,950. The range does not include benefits, and if applicable, bonus, commission, or equity.

Within the range, individual pay is determined by work location and additional factors, including, but not limited to, job-related skills, experience, and relevant education or training. If you are selected to move forward, the recruiting team will provide details specific to the factors above.

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to [email protected]

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants.

Please visit our career page at: http://www.guardanthealth.com/jobs/